TY - JOUR
AU - Wu, Xiaodong
AU - Li, Chenghong
AU - Chen, Shi
AU - Zhang, Xin
AU - Wang, Feilong
AU - Shi, Ting
AU - Li, Qiang
AU - Lin, Lin
PY - 2021
DA - March
TI - Association of body mass index with severity and mortality of COVID-19 pneumonia: a two-center, retrospective cohort study from Wuhan, China
JO - Aging
EP - 7780
VL - 13
IS - 6
DO - https://doi.org/10.18632/aging.202813
AB - In this study, we aimed to investigate the relationship between body mass index (BMI) and multiple severe outcomes of the coronavirus disease 2019 (COVID-19) pneumonia. A total of 1091 patients hospitalized with COVID-19 pneumonia were included from Wuhan, China. Overall, 2.8% (n = 31) received invasive mechanical ventilation (IMV), 10.8% (n = 118) were admitted to the intensive care unit (ICU), 6.4% (n = 70) developed acute respiratory distress syndrome (ARDS), and 4.4% (n = 48) died. Multivariable-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of IMV therapy, ICU admission and ARDS associated with obesity were 2.86 (1.16-7.05), 2.62 (1.52-4.49) and 3.15 (1.69-5.88), respectively; underweight was significantly associated with death (HR 3.85, 95%CI 1.26-11.76). Restricted cubic spline analyses suggested U-shaped associations of BMI with ICU admission and death, but linear relationships of BMI with IMV therapy and ARDS. In conclusion, obesity had an increased risk of IMV therapy, ICU admission and ARDS, while underweight was associated with higher mortality in COVID-19 pneumonia. U-shaped associations of BMI with ICU admission and death, and linear relationships of BMI with IMV therapy and ARDS, were found. These findings indicate that extra caution should be taken when treating COVID-19 patients with underweight and obesity.
PB - Impact Journals
UR - https://www.research.ed.ac.uk/portal/en/publications/association-of-body-mass-index-with-severity-and-mortality-of-covid19-pneumonia(45f99635-1a95-4d62-aac9-bcdb2957d7f3).html
KW - Coronavirus (COVID-19)
ER