TY - JOUR
AU - Bousquet, Jean
AU - Czarlewski, Wienczyslawa
AU - Zuberbier, Torsten
AU - Mullol, Joaquim
AU - Blain, Hubert
AU - Cristol, Jean-Paul
AU - de la Torre, Rafael
AU - Pizarro Lozano, Nieves
AU - Le Moing, Vincent
AU - Bedbrook, Anna
AU - Agache, Ioana
AU - Akdis, Cezmi A.
AU - Canonica, G. Walter
AU - Cruz, Alvaro A.
AU - Fiocchi, Alessandro
AU - Fonseca, João A.
AU - Fonseca, Susana
AU - Gemicioğlu, Bilun
AU - Haahtela, Tari
AU - Iaccarino, Guido
AU - Ivancevich, Juan Carlos
AU - Jutel, Marek
AU - Klimek, Ludger
AU - Kraxner, Helga
AU - Kuna, Piotr
AU - Larenas-Linnemann, Désirée E.
AU - Martineau, Adrian R.
AU - Melén, Erik
AU - Okamoto, Yoshitaka
AU - Papadopoulos, Nikolaos G.
AU - Pfaar, Oliver
AU - Regateiro, Frederico S.
AU - Reynes, Jacques
AU - Rolland, Yves
AU - Rouadi, Philip W
AU - Samolinski, Boleslaw
AU - Sheikh, Aziz
AU - Toppila-Salmi, Sanna
AU - Valiulis, Arunas
AU - Choi, Hak-Jong
AU - Kim, Hyun Ju
AU - Antó, Josep M.
PY - 2021
DA - February
TI - Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19
JO - International Archives of Allergy and Immunology
EP - 338
VL - 182
IS - 4
DO - https://doi.org/10.1159/000514204
AB - In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
PB - S. Karger AG
UR - https://www.research.ed.ac.uk/en/publications/potential-interplay-between-nrf2-trpa1-and-trpv1-in-nutrients-for
KW - Coronavirus (COVID-19)
ER