TY - JOUR
AU - Wei, Jia
AU - Stoesser, Nicole
AU - Matthews, Philippa C.
AU - Ayoubkhani, Daniel
AU - Studley, Ruth
AU - Bell, Iain
AU - Bell, John I.
AU - Newton, John N.
AU - Farrar, Jeremy
AU - Diamond, Ian
AU - Rourke, Emma
AU - Howarth, Alison
AU - Marsden, Brian D.
AU - Hoosdally, Sarah
AU - Jones, E. Yvonne
AU - Stuart, David I.
AU - Crook, Derrick W.
AU - Peto, Timothy E.A.
AU - Pouwels, Koen B.
AU - Eyre, David W.
AU - Walker, A. Sarah
AU - Lambert, Alex
AU - Thomas, Tina
AU - Black, Russell
AU - Felton, Antonio
AU - Crees, Megan
AU - Jones, Joel
AU - Lloyd, Lina
AU - Sutherland, Esther
AU - Pritchard, Emma
AU - Vihta, Karina-Doris
AU - Doherty, George
AU - Kavanagh, James
AU - Chau, Kevin K.
AU - Hatch, Stephanie B.
AU - Ebner, Daniel
AU - Ferreira, Lucas Martins
AU - Christott, Thomas
AU - Dejnirattisai, Wanwisa
AU - Mongkolsapaya, Juthathip
AU - Cameron, Sarah
AU - Tamblin-Hopper, Phoebe
AU - Wolna, Magda
AU - Brown, Rachel
AU - Cornall, Richard
AU - Screaton, Gavin
AU - Lythgoe, Katrina A.
AU - Bonsall, David
AU - Golubchik, Tanya
AU - Fryer, Helen
AU - Cox, Stuart
AU - Paddon, Kevin
AU - James, Tim
AU - House, Thomas
AU - Robotham, Julie
AU - Birrell, Paul J.
AU - Jordan, Helena
AU - Sheppard, Tim
AU - Athey, Graham
AU - Moody, Dan
AU - Curry, Leigh
AU - Brereton, Pamela
AU - Jarvis, Ian
AU - Godsmark, Anna
AU - Morris, George
AU - Mallick, Bobby
AU - Eeles, Phil
AU - Hay, Jodie
AU - VanSteenhouse, Harper
AU - Lee, Jessica
PY - 2021
DA - September
TI - Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom
JO - Nature Microbiology
EP - 1149
VL - 6
IS - 9
DO - https://doi.org/10.1038/s41564-021-00947-3
AB - We report that in a cohort of 45,965 adults, who were receiving either the ChAdOx1 or the BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection with SARS-CoV-2, seroconversion rates and quantitative antibody levels after a single dose were lower in older individuals, especially in those aged &gt;60 years. Two vaccine doses achieved high responses across all ages. Antibody levels increased more slowly and to lower levels with a single dose of ChAdOx1 compared with a single dose of BNT162b2, but waned following a single dose of BNT162b2 in older individuals. In descriptive latent class models, we identified four responder subgroups, including a ‘low responder’ group that more commonly consisted of people aged &gt;75 years, males and individuals with long-term health conditions. Given our findings, we propose that available vaccines should be prioritized for those not previously infected and that second doses should be prioritized for individuals aged &gt;60 years. Further data are needed to better understand the extent to which quantitative antibody responses are associated with vaccine-mediated protection.
PB - Springer Nature
UR - http://eprints.gla.ac.uk/250653/
KW - Coronavirus (COVID-19)
KW - Immunisation and screening
ER