TY - JOUR
AU - Sattar, Naveed
AU - Valabhji, Jonathan
PY - 2021
DA - August
TI - Obesity as a risk factor for severe COVID-19: summary of the best evidence and implications for health care
JO - Health Services and Programs 
EP - 289
VL - 10
DO - https://doi.org/10.1007/s13679-021-00448-8
AB - Purpose of Review: To collate the best evidence from several strands—epidemiological, genetic, comparison with historical data and mechanistic information—and ask whether obesity is an important causal and potentially modifiable risk factor for severe COVID-19 outcomes. Recent Findings: Several hundred studies provide powerful evidence that body mass index (BMI) is a strong linear risk factor for severe COVID-19 outcomes, with recent studies suggesting ~5-10% higher risk for COVID-19 hospitalisation per every kg/m2 higher BMI. Genetic data concur with hazard ratios increasing by 14% per every kg/m2 higher BMI. BMI to COVID-19 links differ markedly from prior BMI-infection associations and are further supported as likely causal by multiple biologically plausible pathways. Summary: Excess adiposity appears to be an important, modifiable risk factor for adverse COVID-19 outcomes across all ethnicities. The pandemic is also worsening obesity levels. It is imperative that medical systems worldwide meet this challenge by upscaling investments in obesity prevention and treatments.
PB - Springer Nature
UR - http://eprints.gla.ac.uk/246903/
KW - Coronavirus (COVID-19)
ER