TY - JOUR
AU - Anderson, Jana J.
AU - Ho, Frederick K.
AU - Niedzwiedz, Claire L.
AU - Katikireddi, Srinivasa Vittal
AU - Celis-Morales, Carlos A.
AU - Iliodromiti, Stamatina
AU - Welsh, Paul
AU - Pellicori, Pierpaolo
AU - Demou, Evangelia
AU - Hastie, Claire E.
AU - Lyall, Donald M.
AU - Gray, Stuart R.
AU - Forbes, John F.
AU - Gill, Jason M.R.
AU - Mackay, Daniel F.
AU - Berry, Colin
AU - Cleland, John G.F.
AU - Sattar, Naveed
AU - Pell, Jill P.
PY - 2021
DA - July
TI - Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study
JO - Journal of Thrombosis and Haemostasis
EP - 6
IS - 00
DO - http://dx.doi.org/10.1111/jth.15452
AB - Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of venous thromboembolism. However, it is unclear whether remote history (&gt;9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006-2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19 related hospital admissions and COVID-19 deaths. The risk of COVID-19 hospitalisation or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for socio-demographic, lifestyle and comorbid covariates. Results: After adjustment for socio-demographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with non-fatal community (RR 1.61, 95% CI 1.02-2.54, p=0.039), non-fatal hospitalised (RR 1.52, 95% CI 1.06-2.17, p=0.024) and severe (hospitalised or fatal) (RR 1.40, 95% CI 1.04-1.89, p=0.025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14-2.42, p=0.009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66-1.74, p=0.786). Conclusion: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.
PB - Wiley
UR - http://eprints.gla.ac.uk/245607/
KW - Coronavirus (COVID-19)
ER