TY - JOUR
AU - Morton, Ben
AU - Barnes, Kayla G.
AU - Anscombe, Catherine
AU - Jere, Khuzwayo
AU - Matambo, Prisca
AU - Mandolo, Jonathan
AU - Kamng’ona, Raphael
AU - Brown, Comfort
AU - Nyirenda, James
AU - Phiri, Tamara
AU - Banda, Ndaziona P.
AU - Van Der Veer, Charlotte
AU - Mndolo, Kwazizira S.
AU - Mponda, Kelvin
AU - Rylance, Jamie
AU - Phiri, Chimota
AU - Mallewa, Jane
AU - Nyirenda, Mulinda
AU - Katha, Grace
AU - Kambiya, Paul
AU - Jafali, James
AU - Mwandumba, Henry C.
AU - Gordon, Stephen B.
AU - Cornick, Jennifer
AU - Jambo, Kondwani C.
AU - Blantyre COVID-19 Consortium
PY - 2021
DA - June
TI - Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa
JO - Nature Communications
VL - 12
DO - https://doi.org/10.1038/s41467-021-23267-w
AB - Abstract: Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.
PB - Springer Nature
UR - http://eprints.gla.ac.uk/243949/
KW - Coronavirus (COVID-19)
KW - Hospital care
KW - Immunisation and screening
ER