TY - JOUR
AU - McGovern, Josh
AU - Dolan, Ross
AU - Richards, Conor
AU - Laird, Barry J.
AU - McMillan, Donald C.
AU - Maguire, Donogh
PY - 2021
DA - August
TI - Relation between body composition, systemic inflammatory response, and clinical outcomes in patients admitted to an urban teaching hospital with COVID-19
JO - Journal of Nutrition
EP - 2244
VL - 151
IS - 8
DO - https://doi.org/10.1093/jn/nxab142
AB - Background: COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. Objectives: The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19. Methods: Patients who presented to our institution between March 17 and May 1, 2020, with a positive PCR test for COVID-19 or characteristic radiological changes, were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, poGPS, NLR , CT-BC measurements, and clinical outcomes including ITU admission and 30-d mortality, of those admitted. Results: Sixty-three patients met the study inclusion criteria. Forty-two patients (67%) were aged ≥70 y, 30 (47.6%) were male and 34.9% ( n = 22) had a poGPS ≥1. ITU admission was significantly associated with a high VFA ( P &lt; 0.05). Thirty-day mortality was associated with high VFA (P &lt; 0.05) and low SMI (P &lt; 0.05). Conclusions: Sarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality.
PB - Oxford University Press
UR - http://eprints.gla.ac.uk/243884/
KW - Coronavirus (COVID-19)
KW - Education
KW - Hospital care
ER