TY - JOUR
AU - Alroomi, Moudhi
AU - Rajan, Rajesh
AU - Omar, Abdulaziz A.
AU - Alsaber, Ahmad R.
AU - Pan, Jiazhu
AU - Fatemi, Mina
AU - Zhanna, Kobalava D.
AU - Aboelhassan, Wael
AU - Almutairi, Farah
AU - Alotaibi, Naser
AU - Saleh, Mohammad A.
AU - AlNasrallah, Noor
AU - Al-Bader, Bader
AU - Malhas, Haya
AU - Ramadhan, Maryam
AU - Abdullah, Mohammed
AU - Abdelnaby, Hassan
PY - 2021
DA - August
TI - Ferritin level: a predictor of severity and mortality in hospitalized COVID-19 patients
JO - Immunity, Inflammation and Disease
EP - 8
DO -  https://doi.org/10.1002/iid3.517
AB - Introduction: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.  Methods: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or &gt;1000).  Results: Approximately 89% (118) of the patients with ferritin levels &gt; 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21–0.62; p &lt;.001), male sex (OR = 2.63, 95% CI = 1.43–5.06; p =.003), hypertension (OR = 4.16, 95% CI = 2.42–7.36; p &lt;.001) and pneumonia (OR = 8.48, 95% CI = 3.02–35.45; p &lt;.001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan–Meier survival probability plot showed a higher mortality rate among patients with ferritin levels &gt; 1000.  Conclusion: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.
PB - Wiley
UR - https://strathprints.strath.ac.uk/77474/
KW - Coronavirus (COVID-19)
KW - Hospital care
ER