TY - JOUR
AU - Pieretti, Joana C.
AU - Rubilar, Olga
AU - Weller, Richard B.
AU - Tortella, Gonzalo R.
AU - Seabra, Amedea B.
PY - 2020
DA - October
TI - Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections
JO - Virus Research
VL - 291
DO - https://doi.org/10.1016/j.virusres.2020.198202
AB - The endogenous free radical nitric oxide (NO) plays a pivotal role in the immunological system. NO has already been reported as a potential candidate for use in the treatment of human coronavirus infections, including COVID-19. In fact, inhaled NO has been used in clinical settings for its antiviral respiratory action, and in the regulation of blood pressure to avoid clot formation. In this mini-review, we discuss recent progress concerning the antivirus activity of NO in clinical, pre-clinical and research settings, and its beneficial effects in the treat-ment of clinical complications in patients infected with coronaviruses and other respiratory viral diseases, including COVID-19. We also highlight promising therapeutic effects of NO donors allied to nanomaterials to combat COVID-19 and other human coronavirus infections. Nanomaterials can be designed to deliver sustained, localized NO release directly at the desired application site, enhancing the beneficial effects of NO and mini-mizing the side effects. Challenges and perspectives are presented to open new fields of research.
PB - Elsevier
UR - https://www.research.ed.ac.uk/en/publications/a97b9e3c-4ced-4f78-8519-ebbd00233a4d
KW - Coronavirus (COVID-19)
KW - Research methods
ER