TY - JOUR
AU - Martin, Darren P.
AU - Weaver, Steven
AU - Tegally, Houriiyah
AU - San, James Emmanuel
AU - Shank, Stephen D.
AU - Wilkinson, Eduan
AU - Lucaci, Alexander G.
AU - Giandhari, Jennifer
AU - Naidoo, Sureshnee
AU - Pillay, Yeshnee
AU - Singh, Lavanya
AU - Lessells, Richard J.
AU - Gupta, Ravindra K.
AU - Wertheim, Joel O.
AU - Nekrutenko, Anton
AU - Murrell, Ben
AU - Harkins, Gordon W.
AU - Lemey, Philippe
AU - MacLean, Oscar A.
AU - Robertson, David L.
AU - De Oliveira, Tulio
AU - Kosakovsky Pond, Sergei L.
PY - 2021
DA - September
TI - The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages
JO - Cell
EP - 5200.e7
VL - 184
IS - 20
DO - http://dx.doi.org/10.1016/j.cell.2021.09.003
AB - The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three “501Y lineages” coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.
PB - Elsevier
UR - http://eprints.gla.ac.uk/252906/
KW - Coronavirus (COVID-19)
ER