TY - JOUR
AU - Stock, Sarah J.
AU - Carruthers, Jade
AU - Calvert, Clara
AU - Denny, Cheryl
AU - Donaghy, Jack
AU - Goulding, Anna
AU - Hopcroft, Lisa E.M.
AU - Hopkins, Leanne
AU - McLaughlin, Terry
AU - Pan, Jiafeng
AU - Shi, Ting
AU - Taylor, Bob
AU - Agrawal, Utkarsh
AU - Auyeung, Bonnie
AU - Katikireddi, Srinivasa Vittal
AU - McCowan, Colin
AU - Murray, Josephine-Louise K.
AU - Simpson, Colin R.
AU - Chris Robertson
AU - Vasileiou, Eleftheria
AU - Sheikh, Aziz
AU - Wood, Rachael
PY - 2022
DA - January
TI - SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland
JO - Nature Medicine
DO - https://doi.org/10.1038/s41591-021-01666-2
AB - Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18−44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9−38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1−6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2−78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7−92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5−99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic.
PB - Springer Nature
UR - https://publichealthscotland.scot/id/51370
KW - Coronavirus (COVID-19)
KW - Maternity and early years
KW - Immunisation and screening
ER