TY - JOUR AU - Hall, Victoria J. AU - Foulkes, Sarah AU - Insalata, Ferdinando AU - Saei, Ayoub AU - Kirwan, Peter D. AU - Atti, Ana AU - Wellington, Edgar AU - Khawam, Jameel AU - Munro, Katie AU - Cole, Michelle J. AU - Tranquillini, Caio AU - Taylor-Kerr, Andrew AU - Hettiarachchi, Nipunadi AU - Calbraith, Davina AU - Sajedi, Noshin AU - Milligan, Iain AU - Themistocleous, Yrene AU - Corrigan, Diane AU - Cromey, Lisa AU - Price, Lesley AU - Stewart, Sally AU - De Lacy, Elen AU - Norman, Chris AU - Linley, Ezra AU - Otter, Ashley David AU - Semper, Amanda AU - Hewson, Jacqueline AU - D'Arcangelo, Silvia AU - SIREN Study Group AU - Chand, Meera AU - Brown, Colin S. AU - Brooks, Tim AU - Islam, Jasmin AU - Charlett, Andre AU - Hopkins, Susan PY - 2021 DA - December TI - Effectiveness and durability of protection against future SARS-CoV-2 infection conferred by COVID-19 vaccination and previous infection; findings from the UK SIREN prospective cohort study of healthcare workers March 2020 to September 2021 JO - MedRxiv DO - https://doi.org/10.1101/2021.11.29.21267006 AB - BackgroundUnderstanding the duration and effectiveness of infection and vaccine-acquired SARS-CoV-2 immunity is essential to inform pandemic policy interventions, including the timing of vaccine-boosters. We investigated this in our large prospective cohort of UK healthcare workers undergoing routine asymptomatic PCR testing. PB - medRxiv UR - https://publichealthscotland.scot/id/57519 KW - Coronavirus (COVID-19) KW - Immunisation and screening KW - Work and workforce ER