TY - JOUR
AU - Jeffreys, Laura N.
AU - Pennington, Shaun H.
AU - Duggan, Jack
AU - Caygill, Claire H.
AU - Lopeman, Rose C.
AU - Breen, Alastair F.
AU - Jinks, Jessica B.
AU - Ardrey, Alison
AU - Donnellan, Samantha
AU - Patterson, Edward I.
AU - Hughes, Grant L.
AU - Hong, David W.
AU - O'Neill, Paul M.
AU - Aljayyoussi, Ghaith
AU - Owen, Andrew
AU - Ward, Stephen A
AU - Biagini, Giancarlo A
PY - 2022
DA - January
TI - Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2
JO - International Journal of Antimicrobial Agents
VL - 59
IS - 3
DO - https://doi.org/10.1016/j.ijantimicag.2022.106542
AB - A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advantages over monotherapies, including the potential to achieve greater efficacy, the potential to increase the therapeutic index of drugs and the potential to reduce the emergence of drug resistance. Here, we report on the in vitro synergistic interaction between two FDA approved drugs, remdesivir and ivermectin resulting in enhanced antiviral activity against SARS-CoV-2. Whilst the in vitro synergistic activity reported here does not support the clinical application of this combination treatment strategy, due to insufficient exposure of ivermectin in vivo, the data do warrant further investigation. Efforts to define the mechanisms underpinning the observed synergistic action, could lead to the development of novel therapeutic treatment strategies.
PB - Elsevier
UR - http://researchrepository.napier.ac.uk/Output/2845755
KW - Coronavirus (COVID-19)
ER