TY - JOUR
AU - da Silva Filipe, Ana
AU - Shepherd, James G.
AU - Williams, Thomas
AU - Hughes, Joseph
AU - Aranday-Cortes, Elihu
AU - Asamaphan, Patawee
AU - Ashraf, Shirin
AU - Balcazar, Carlos E.
AU - Brunker, Kirstyn
AU - Campbell, Alasdair
AU - Carmichael, Stephen
AU - Davis, Christopher
AU - Dewar, Rebecca
AU - Gallagher, Michael D.
AU - Gunson, Rory N.
AU - Hill, Verity
AU - Ho, Antonia
AU - Jackson, Ben
AU - James, Edward
AU - Jesudason, Natasha
AU - Johnson, Natasha
AU - Leitch, E. Carol McWilliam
AU - Li, Kathy K.
AU - MacLean, Alasdair
AU - Mair, Daniel
AU - McAllister, David A.
AU - McCrone, John T.
AU - McDonald, Sarah E.
AU - McHugh, Martin P.
AU - Morris, A. Keith
AU - Nichols, Jenna
AU - Niebel, Marc O.
AU - Nomikou, Kyriaki
AU - Orton, Richard J.
AU - O'Toole, Áine Niamh
AU - Palmarini, Massimo
AU - Parcell, Benjamin J.
AU - Parr, Yasmin A.
AU - Rambaut, Andrew
AU - Rooke, Stefan
AU - Shabaan, Sharif
AU - Shah, Rajiv N.
AU - Singer, Joshua B.
AU - Smollett, Katherine
AU - Starinskij, Igor
AU - Tong, Lily
AU - Sreenu, Vattipally B.
AU - Wastnedge, Elizabeth
AU - Holden, Matthew T.G.
AU - Robertson, David L.
AU - Templeton, Kate E.
AU - Thomson, Emma C.
PY - 2021
DA - January
TI - Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland
JO - Nature Microbiology
EP - 122
VL - 6
IS - 1
DO - https://doi.org/10.1038/s41564-020-00838-z
AB - Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and epidemiological approach. Sequencing of 1,314 SARS-CoV-2 viral genomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotland on at least 283 occasions during February and March 2020. Epidemiological analysis confirmed that early introductions of SARS-CoV-2 originated from mainland Europe (the majority from Italy and Spain). We identified subsequent early outbreaks in the community, within healthcare facilities and at an international conference. Community transmission occurred after 2 March, 3 weeks before control measures were introduced. Earlier travel restrictions or quarantine measures, both locally and internationally, would have reduced the number of COVID-19 cases in Scotland. The risk of multiple reintroduction events in future waves of infection remains high in the absence of population immunity.
PB - Springer Nature
PB - Wellcome Trust
UR - http://eprints.gla.ac.uk/231918/
KW - Coronavirus (COVID-19)
ER