TY - JOUR AU - Al-kuraishy, Hayder M. AU - Al-gareeb, Ali I. AU - Qusti, Safaa AU - Alshammari, Eida M. AU - Zirintunda, Gerald AU - Welburn, Susan C AU - Kasozi, Keneth Iceland AU - El-saber Batiha, Gaber PY - 2021 DA - November TI - Effects of β-blockers on the sympathetic and cytokines storms in Covid-19 JO - Frontiers in Immunology DO - https://doi.org/10.3389/fimmu.2021.749291 AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative virus in the development of coronavirus disease 2019 (Covid-19) pandemic. Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) lead to hypoxia, oxidative stress, and sympatho-activation and in severe cases lead to sympathetic storm (SS). On the other hand, exaggerated immune response to the SARS-CoV-2 invasion may lead to uncontrolled release of pro-inflammatory cytokine development of cytokine storm (CS). In Covid-19, there are interactive interactions between CS and SS in development of multi-organ failure (MOF). Interestingly, cutting the bridge between CS and SS by anti-inflammatory and anti-adrenergic agents may mitigate complications that are induced by SARS-CoV-2 infection in severely affected Covid-19 patients. The potential mechanisms of SS in Covid-19 are through different pathways such as hypoxia, which activate central sympathetic center through carotid bodies chemosensory input and induced pro-inflammatory cytokines, which cross blood brain barrier and activate sympathetic center. β2-receptors signaling pathway play a crucial role in the production of pro-inflammatory cytokines, macrophage activation and B-cells for production of antibodies with inflammation exacerbation. β-blockers have anti-inflammatory effects through reduction release of pro-inflammatory cytokines with inhibition of NF-κB . In conclusion, β-blockers interrupt this interaction through inhibition of several mediators of CS and SS with prevention development of neural-cytokine loop in SARS-CoV-2 infection. Evidences from this study trigger an idea for future prospective studies to confirm the potential role of β-blockers in the management of Covid-19. PB - Frontiers Media UR - https://www.research.ed.ac.uk/en/publications/efa4cb47-79eb-4e4c-a8fa-b0865941db88 KW - Coronavirus (COVID-19) ER