TY - JOUR
AU - Lambe, Teresa
AU - Pollard, Andrew J.
AU - Crook, Derrick W.
AU - Webster, Hermione
AU - Dunachie, Susanna
AU - Barnes, Eleanor
AU - Klenerman, Paul
AU - Carroll, Miles W.
AU - Tan, Tiong Kit
AU - Huang, Kuan-Ying A.
AU - Townsend, Alain
AU - Semple, Malcolm G.
AU - Baillie, J. Kenneth
AU - Openshaw, Peter J.M.
AU - Malik, Tariq 
AU - Nunes, C. Marta
AU - Madhi, Shabir A.
AU - Kwatra, Gaurav
AU - Serafin, Natali 
AU - Baillie, Vicky L.
AU - Siqueira, Marilda M. 
AU - Pauvolid-Correa, Alex
AU - Resende, Paola Cristina
AU - Fernandes da Costa, Cristiano
AU - Nascimento, Fernanda
AU - Nascimento, Valdinete
AU - Naveca, Felipe Gomes
AU - Costa Clemens, Sue Ann
AU - Voysey, Merryn
AU - Aley, Parvinder K.
PY - 2022
DA - January
TI - SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
JO - Cell
EP - 484
VL - 185
IS - 3
DO - https://doi.org/10.1016/j.cell.2021.12.046
AB - On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
PB - Elsevier
UR - https://www.research.ed.ac.uk/en/publications/14d09135-2056-49b5-a449-e0906616d09f
KW - Coronavirus (COVID-19)
ER