TY - JOUR
AU - Zeberg, Hugo
AU - Richards, Brent
AU - Kiryluk, Krzysztof
AU - Baillie, J. Kenneth
AU - Verma, Subodh
AU - Verma, Anurag
AU - Ganna, Andrea
AU - The COVID-19 Host Genetics Initiative
AU - Nakanishi, Tomoko
AU - Peloso, Gina
AU - Drivas, Theodore G. 
AU - Pairo-Castineira, Erola
AU - Khan, Atlas
AU - Butler-Laporte, Guillaume
AU - Huffman, Jennifer E.
PY - 2022
DA - January
TI - Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
JO - Nature Genetics 
EP - 127
VL - 54
DO - https://doi.org/10.1038/s41588-021-00996-8
AB - The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/en/publications/f1c4f37c-ff55-4cfd-89d7-b1385b3d0b8f
KW - Coronavirus (COVID-19)
ER