TY - JOUR
AU - Jackson, Ben
AU - Boni, Maciej F.
AU - Bull, Matthew
AU - Colleran, Amy
AU - Colquhoun, Rachel M.
AU - Darby, Alistair C.
AU - Haldenby, Sam T.
AU - Hill, Verity
AU - Lucaci, Anita O.
AU - McCrone, John T.
AU - Nicholls, Samuel M.
AU - O'Toole, Áine Niamh
AU - Pacchiarini, Nicole
AU - Poplawski, Radoslaw
AU - Scher, Emily
AU - Todd, Flora
AU - Webster, Hermione J.
AU - Whitehead, Mark
AU - Wierzbicki, Claudia
AU - The COVID-19 Genomics UK (COG-UK) Consortium
AU - Loman, Nicholas J.
AU - Connor, Thomas R.
AU - Robertson, David L.
AU - Pybus, Oliver G.
AU - Rambaut, Andrew
PY - 2021
DA - August
TI - Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic
JO - Cell
EP - 5188.e8
VL - 184
IS - 20
DO - https://doi.org/10.1016/j.cell.2021.08.014
AB - We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances, there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of 2 months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7's set of mutations.
PB - Elsevier
UR - https://www.research.ed.ac.uk/en/publications/f9b35aa8-94e9-454d-8d8a-b7307d7f2916
KW - Coronavirus (COVID-19)
ER