TY - JOUR
AU - Nelson, Christopher P.
AU - Sama, Iziah E.
AU - Codd, Veryan
AU - Webb, Thomas R.
AU - Ye, Shu
AU - Lang, Chim C.
AU - Voors, Adriaan A.
AU - Ng, Leong L.
AU - Samani, Nilesh J.
PY - 2020
DA - September
TI - Genetic associations with plasma angiotensin converting enzyme 2 concentration: Potential relevance to COVID-19 risk
JO - Circulation
EP - 1119
VL - 142
IS - 11
DO - https://doi.org/10.1161/CIRCULATIONAHA.120.049007
AB - Male sex has emerged as a major independent risk factor for severe disease and death from severe acute respiratory syndrome coronavirus–related coronavirus disease 2019 (COVID-19).Severe acute respiratory syndrome coronavirus 2 infects cells via the angiotensin converting enzyme 2 (ACE2) receptor, a widely distributed cell-surface receptor.In 2 cohorts of patients with heart failure (BIOSTAT-CHF [Biology Study to Tailored Treatment in Chronic Heart Failure]), we recently showed that age-adjusted plasma concentrations of ACE2 are higher in men than in women.
PB - American Heart Association
UR - https://discovery.dundee.ac.uk/en/publications/bf09ae6a-1646-41a4-892f-55c7a945dade
KW - Coronavirus (COVID-19)
ER