TY - JOUR
AU - Gordon, David E.
AU - Hiatt, Joseph
AU - Bouhaddou, Mehdi
AU - Rezelj, Veronica V.
AU - Ulferts, Svenja
AU - Braberg, Hannes
AU - Jureka, Alexander S.
AU - Obernier, Kirsten
AU - Guo, Jeffrey Z.
AU - Batra, Jyoti
AU - Kaake, Robyn M.
AU - Weckstein, Andrew R.
AU - Owens, Tristan W.
AU - Gupta, Meghna
AU - Pourmal, Sergei
AU - Titus, Erron W
AU - Cakir, Merve
AU - Soucheray, Margaret
AU - McGregor, Michael
AU - Cakir, Zeynep
AU - Jang, Gwendolyn
AU - O'Meara, Matthew J.
AU - Tummino, Tia A.
AU - Zhang, Ziyang
AU - Foussard, Helene
AU - Rojc, Ajda
AU - Zhou, Yuan
AU - Kuchenov, Dmitry
AU - Hüttenhain, Ruth
AU - Xu, Jiewei
AU - Eckhardt, Manon
AU - Swaney, Danielle L.
AU - Fabius, Jacqueline M.
AU - Ummadi, Manisha
AU - Tutuncuoglu, Beril
AU - Rathore, Ujjwal
AU - Modak, Maya
AU - Haas, Paige
AU - Haas, Kelsey M.
AU - Williams, Daniel M.
AU - Hastie, C. James
AU - Elliott, Matthew
AU - Brown, Fiona
AU - Burness, Kerry A.
AU - Reid, Elaine
AU - Baillie, Carla
AU - Raggett, Samantha
AU - Toth, Rachel
AU - Alessi, Dario R.
AU - Davies, Paul
AU - García-Sastre, Adolfo
AU - Rassen, Jeremy A.
AU - Grosse, Robert
AU - Rosenberg, Oren S.
AU - Verba, Kliment A.
AU - Basler, Christopher F.
AU - Vignuzzi, Marco
AU - Peden, Andrew A.
AU - Beltrao, Pedro
AU - Krogan, Nevan J.
PY - 2020
DA - December
TI - Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
JO - Science
VL - 370
IS - 6521
DO - https://doi.org/10.1126/science.abe9403
AB - The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human proteinprotein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARSCoV- 2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.
PB - American Association for the Advancement of Science
UR - https://discovery.dundee.ac.uk/en/publications/42de7dd7-b036-469a-b622-b09d3c239ae7
KW - Coronavirus (COVID-19)
ER