TY - JOUR
AU - Trevelin, Silvia C.
AU - Pickering, Suzanne
AU - Todd, Katrina
AU - Bishop, Cynthia
AU - Pitcher, Michael
AU - Garrido Mesa, Jose
AU - Montorsi, Lucia
AU - Spada, Filomena
AU - Petrov, Nedyalko
AU - Green, Anna
AU - Shankar-Hari, Manu
AU - Neil, Stuart J.D.
AU - Spencer, Jo
PY - 2022
DA - February
TI - Disrupted Peyer’s Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus
JO - Frontiers in Immunology
VL - 13
DO - https://doi.org/10.3389/fimmu.2022.838328
AB - Confirmed SARS-coronavirus-2 infection with gastrointestinal symptoms and changes in microbiota associated with coronavirus disease 2019 (COVID-19) severity have been previously reported, but the disease impact on the architecture and cellularity of ileal Peyer’s patches (PP) remains unknown. Here we analysed post-mortem tissues from throughout the gastrointestinal (GI) tract of patients who died with COVID-19. When virus was detected by PCR in the GI tract, immunohistochemistry identified virus in epithelium and lamina propria macrophages, but not in lymphoid tissues. Immunohistochemistry and imaging mass cytometry (IMC) analysis of ileal PP revealed depletion of germinal centres (GC), disruption of B cell/T cell zonation and decreased potential B and T cell interaction and lower nuclear density in COVID-19 patients. This occurred independent of the local viral levels. The changes in PP demonstrate that the ability to mount an intestinal immune response is compromised in severe COVID-19, which could contribute to observed dysbiosis.
PB - Frontiers Media
UR - https://www.research.ed.ac.uk/en/publications/53e94f49-e06f-4e27-8517-fbbf2eda358e
KW - Coronavirus (COVID-19)
ER