TY - JOUR
AU - Hastie, Claire E.
AU - Foster, Hamish M.E.
AU - Jani, Bhautesh D.
AU - O'Donnell, Catherine A.
AU - Ho, Frederick K.
AU - Pell, Jill P.
AU - Sattar, Naveed
AU - Katikireddi, Srinivasa Vittal
AU - Mair, Frances S.
AU - Nicholl, Barbara I.
PY - 2022
DA - March
TI - Chronic pain and COVID-19 hospitalisation and mortality: A UK Biobank cohort study
JO - Pain
EP - 90
VL - 164
IS - 1
DO - https://doi.org/10.1097/j.pain.0000000000002663
AB - The risk of COVID-19 in those with chronic pain is unknown. We investigated whether self-reported chronic pain was associated with COVID-19 hospitalisation ormortality. UK Biobank recruited 502,624 participants aged 37 to 73 years between 2006 and 2010. Baseline exposure data, including chronic pain (&gt;3 months, in at least 1 of 7 prespecified body sites) and chronic widespread pain (&gt;3 months, all over body), were linked to COVID-19 hospitalisations ormortality. Univariable or multivariable Poisson regression analyses were performed on the association between chronic pain and COVID-19 hospitalisation and Cox regression analyses of the associations with COVID-19mortality. Multivariable analyses adjusted incrementally for sociodemographic confounders, then lifestyle risk factors, and finally long-term condition count. Of 441,403 UK Biobank participants with complete data, 3180 (0.7%) were hospitalised for COVID-19 and 1040 (0.2%) died from COVID-19. Chronic pain was associated with hospital admission for COVID-19 even after adjustment for all covariates (incidence rate ratio 1.16; 95% confidence interval [CI] 1.08-1.24;P&lt; 0.001), as was chronic widespread pain (incidence rate ratio 1.33; 95% CI 1.06-1.66;P= 0.012). There was clear evidence of a dose-response relationship with number of pain sites (fully adjusted globalP-value &lt; 0.001). After adjustment for all covariates, there was no association between chronic pain (HR 1.01; 95% CI 0.89-1.15;P= 0.834) but attenuated association with chronic widespread pain (HR 1.50, 95% CI 1.04-2.16,P-value = 0.032) and COVID-19mortality. Chronic pain is associated with higher risk of hospitalisation for COVID-19, but the association withmortalityis unclear. Future research is required to investigate these findings further and determine whether pain is associated with long COVID.
PB - Wolters Kluwer
UR - http://eprints.gla.ac.uk/267518/
KW - Coronavirus (COVID-19)
KW - Hospital care
ER