TY - JOUR
AU - Bruce, Eilidh
AU - Barlow-Pay, Fenella
AU - Short, Roxanna
AU - Vilches-Moraga, Arturo
AU - Price, Angeline
AU - McGovern, Aine
AU - Braude, Philip
AU - Stechman, Michael J.
AU - Moug, Susan J.
AU - McCarthy, Kathryn
AU - Hewitt, Jonathan
AU - Carter, Ben
AU - Myint, Phyo Kyaw
PY - 2020
DA - August
TI - Prior Routine use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
JO - Journal of Clinical Medicine
VL - 9
IS - 8
DO - https://doi.org/10.3390/jcm9082586
AB - Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase the expression of angiotensin-converting enzyme 2 (ACE2), a binding target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter the host cell, which could lead to poorer outcomes in COVID-19 disease.  The aim of this study was to examine the association between routine use of NSAIDs and outcomes in hospitalised patients with COVID-19. This was a multicentre, observational study, with data collected from adult patients with COVID-19 admitted to eight UK hospitals. Of 1222 patients eligible to be included, 54 (4.4%) were routinely prescribed NSAIDs prior to admission. Univariate results suggested a modest protective effect from the use of NSAIDs, but in the multivariable analysis, there was no association between prior NSAID use and time to mortality (adjusted HR (aHR) = 0.89, 95% CI 0.52–1.53,p= 0.67) or length of stay (aHR 0.89, 95% CI 0.59–1.35,p= 0.58).  This study found no evidence that routine NSAID use was associated with higher COVID-19 mortality in hospitalised patients; therefore, patients should be advised to continue taking these medications until further evidence emerges. Our findings suggest that NSAID use might confer a modest benefit with regard to survival. However, as this finding was underpowered, further research is required.
PB - MDPI
UR - https://aura.abdn.ac.uk/handle/2164/14890
KW - Coronavirus (COVID-19)
KW - Hospital care
ER