TY - JOUR
AU - Alexander, Steve
AU - Armstrong, Jane
AU - Davenport, Anthony P.
AU - Davies, Jamie
AU - Faccenda, Elena
AU - Harding, Simon
AU - Levi-Schaffer, Francesca
AU - Maguire, Janet J
AU - Pawson, Adam
AU - Southan, Christopher
AU - Spedding, Michael
PY - 2020
DA - May
TI - A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development
JO - British Journal of Pharmacology
EP - 4966
VL - 177
IS - 21
DO - https://doi.org/10.1111/bph.15094
AB - In this review, we identify opportunities for drug discovery in the treatment of COVID‐19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targetting key host and viral targets in the mid‐term, by first screening these targets against drugs already licensed; an agenda for drug re‐purposing, which should allow rapid translation to clinical trials. A simultaneous, multi‐pronged approach using conventional drug discovery methodologies aimed at discovering novel chemical and biological means targetting a short‐list of host and viral entities should extend the arsenal of anti‐SARS‐CoV‐2 agents. This longer‐term strategy would provide a deeper pool of drug choices for future‐proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide.
PB - Wiley
UR - https://www.research.ed.ac.uk/portal/en/publications/a-rational-roadmap-for-sarscov2covid19-pharmacotherapeutic-research-and-development(f8eff263-67be-4b13-aad7-1186233294a1).html
KW - Coronavirus (COVID-19)
ER