TY - JOUR AU - Pascall, David J. AU - Mollett, Guy AU - Vink, Elen AU - Shepherd, James G. AU - Williams, Thomas AU - Wastnedge, Elizabeth AU - Blacow, Rachel AU - Hughes, Joseph AU - Robertson, David L. AU - Lycett, Samantha J. AU - Bulteel, Naomi AU - Campbell, Robyn AU - Campbell, Alasdair AU - Clifford, Sarah AU - Davis, Chris AU - da Silva Filipe, Ana AU - Fjodorova, Ludmila AU - Forrest, Ruth AU - Goldstein, Emily AU - Gunson, Rory N. AU - Haughney, John AU - Holden, Matthew T.G. AU - Honour, Patrick AU - James, Edward AU - Lewis, Tim AU - McHugh, Martin P. AU - Onishi, Yusuke AU - Parcell, Benjamin J. AU - Sakka, Noha El AU - Shabaan, Sharif AU - Smollett, Katherine AU - Templeton, Kate AU - The COVID-19 Genomics UK (COG-UK) Consortium AU - Thomson, Emma C. PY - 2022 DA - February TI - The SARS-CoV-2 Alpha variant caused increased clinical severity of disease in Scotland: a genomics-based prospective cohort analysis JO - MedRxiv DO - https://doi.org/10.1101/2021.08.17.21260128 AB - BackgroundThe SARS-CoV-2 Alpha variant was associated with increased transmission relative to other variants present at the time of its emergence and several studies have shown an association between Alpha variant infection and increased hospitalisation and 28-day mortality. However, none have addressed the impact on maximum severity of illness in the general population classified by the level of respiratory support required, or death. PB - medRxiv UR - https://publichealthscotland.scot/id/83302 KW - Coronavirus (COVID-19) ER