TY - JOUR
AU - Relph, Katharine A
AU - Russell, Clark D.
AU - Fairfield, Cameron J.
AU - Turtle, Lance C.W.
AU - de Silva, Thushan I.
AU - Siggins, Matthew K
AU - Drake, Thomas M.
AU - Thwaites, Ryan S
AU - Abrams, Simon
AU - Moore, Shona C.
AU - Hardwick, Hayley E.
AU - Oosthuyzen, Wilna
AU - Harrison, Ewen M.
AU - Docherty, Annemarie B.
AU - Openshaw, Peter J.M.
AU - Baillie, J. Kenneth
AU - Semple, Malcolm G.
AU - Ho, Antonia
AU - ISARIC4C Investigators
PY - 2022
DA - May
TI - Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
JO - Open Forum Infectious Diseases
VL - 9
IS - 5
DO - https://doi.org/10.1093/ofid/ofac179
AB - Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).
PB - Oxford University Press
UR - https://www.research.ed.ac.uk/en/publications/02859191-29da-427e-9d92-c4cc29f1c586
KW - Coronavirus (COVID-19)
ER