TY - JOUR
AU - Wilkinson, Sam A.G.
AU - Richter, Alex
AU - Casey, Anna
AU - Osman, Husam
AU - Mirza, Jeremy
AU - Stockton, Joanne
AU - Quick, Joshua
AU - Ratcliffe, Liz
AU - Sparks, Natalie
AU - Cumley, Nicola
AU - Poplawski, Radoslaw
AU - Nicholls, Samuel M.
AU - Kele, Beatrix
AU - Harris, Kathryn
AU - COVID-19 Genomics UK (COG-UK) consortium
AU - Peacock, Thomas P.
AU - Loman, Nicholas J.
PY - 2022
DA - March
TI - Recurrent SARS-CoV-2 Mutations in Immunodeficient Patients [pre-print]
JO - medRxiv
DO - https://doi.org/10.1101/2022.03.02.22271697
AB - Long-term SARS-CoV-2 infections in immunodeficient patients are an important source of variation for the virus but are understudied. Many case studies have been published which describe one or a small number of long-term infected individuals but no study has combined these sequences into a cohesive dataset. This work aims to rectify this and study the genomics of this patient group through a combination of literature searches as well as identifying new case series directly from the COG-UK dataset. The spike gene receptor binding domain (RBD) and N-terminal domains (NTD) were identified as mutation hotspots. Numerous mutations associated with variants of concern were observed to emerge recurrently. Additionally a mutation in the envelope gene, - T30I was determined to be the most recurrent frequently occurring mutation arising in persistent infections. A high proportion of recurrent mutations in immunodeficient individuals are associated with ACE2 affinity, immune escape, or viral packaging optimisation.
PB - medRxiv
UR - https://publichealthscotland.scot/id/87355
KW - Coronavirus (COVID-19)
ER