TY - JOUR
AU - Kemp, Steven A.
AU - Cheng, Mark T. K.
AU - Hamilton, William L.
AU - Kamelian, Kimia
AU - Chauhan, Himanshu
AU - Dikid, Tanzin
AU - Gogia, Hema
AU - Lall, Hemlata
AU - Ponnusamy, Kalaiarasan
AU - Verma, Kaptan
AU - Dhar, Mahesh Shanker
AU - Singh, Manoj K.
AU - Datta, Meena
AU - Soni, Namita
AU - Meena, Namonarayan
AU - Madan, Preeti
AU - Singh, Priyanka
AU - Sharma, Ramesh
AU - Sharma, Rajeev
AU - Kabra, Sandhya
AU - Kumar, Sattender
AU - Kumari, Swati
AU - Sharma, Uma
AU - Chaudhary, Urmila
AU - Sivasubbu, Sridhar
AU - Scaria, Vinod
AU - Wattal, Chand
AU - Oberoi, J. K.
AU - Raveendran, Reena
AU - Datta, S.
AU - Das, Saumitra
AU - Maitra, Arindam
AU - Chinnaswamy, Sreedhar
AU - Biswas, Nidhan Kumar
AU - Parida, Ajay
AU - Raghav, Sunil K.
AU - Prasad, Punit
AU - Sarin, Apurva
AU - Mayor, Satyajit
AU - Ramakrishnan, Uma
AU - Palakodeti, Dasaradhi
AU - Seshasayee, Aswin Sai Narain
AU - Thangaraj, K.
AU - Bashyam, Murali Dharan
AU - Dalal, Ashwin
AU - Bhat, Manoj
AU - Shouche, Yogesh
AU - Pillai, Ajay
AU - Abraham, Priya
AU - Potdar, Varsha Atul
AU - Cherian, Sarah S.
AU - Desai, Anita Sudhir
AU - Pattabiraman, Chitra
AU - Manjunatha, M. V.
AU - Mani, Reeta S.
AU - Udupi, Gautam Arunachal
AU - Nandicoori, Vinay
AU - Tallapaka, Karthik Bharadwaj
AU - Sowpati, Divya Tej
AU - Singh, Sujit
AU - Rakshit, Partha
AU - Agrawal, Anurag
AU - Illingworth, Christopher J.R.
AU - Gupta, Ravindra K.
PY - 2022
DA - June
TI - Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers
JO - Scientific Reports
VL - 12
IS - 1
DO - http://dx.doi.org/10.1038/s41598-022-14411-7
AB - Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure.
PB - Springer Nature
UR - http://eprints.gla.ac.uk/273627/
KW - Coronavirus (COVID-19)
KW - Immunisation and screening
KW - Work and workforce
ER