TY - JOUR
AU - Gualano, Bruno
AU - Lemes, Ítalo Ribeiro
AU - da Silva, Rafael Pires
AU - Pinto, Ana Jéssica
AU - Mazzolani, Bruna Caruso
AU - Smaira, Fabiana Infante
AU - Sieczkowska, Sofia Mendes
AU - Aikawa, Nádia Emi
AU - Pasoto, Sandra
AU - Medeiros-Ribeiro, Ana C.
AU - Saad, Carla
AU - Yuk, Emily
AU - Silva, Clovis
AU - Swinton, Paul
AU - Hallal, Pedro C.
AU - Roschel, Hamilton
AU - Bonfa, Eloisa
PY - 2022
DA - July
TI - Physical activity and antibody persistence 6 months after the second dose of coronavac in immunocompromised patients.
JO - Scandinavian Journal of Medicine and Science in Sports
DO - https://doi.org/10.1111/sms.14213
AB - This prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n=748). Persistent immunogenicity 6 months after the full-course vaccination was assessed using seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire. Adjusted point estimates from logistic regression models indicated greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]) in physically active patients and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full-course of an inactivated SARS-CoV-2 vaccine.
PB - Wiley
UR - https://rgu-repository.worktribe.com/output/1705908
KW - Coronavirus (COVID-19)
KW - Diet, healthy weight and physical activity
KW - Immunisation and screening
ER