TY - JOUR
AU - Prasad, Smriti
AU - Kalafat, Erkan
AU - Blakeway, Helena
AU - Townsend, Rosemary
AU - O'Brien, Pat
AU - Morris, Edward
AU - Draycott, Tim
AU - Thangaratinam, Shakila
AU - Le Doare, Kirsty
AU - Ladhani, Shamez N.
AU - von Dadelszen, Peter
AU - Magee, Laura A.
AU - Heath, Paul T.
AU - Khalil, Asma
PY - 2022
DA - May
TI - Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy
JO - Nature Communications
VL - 13
IS - 1
DO - https://doi.org/10.1038/s41467-022-30052-w
AB - Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effectiveness of mRNA vaccination against RT-PCR confirmed SARS-CoV-2 infection 7 days after second dose was 89·5% (95% CI 69·0-96·4%, 18,828 vaccinated pregnant people, I2 = 73·9%). The risk of stillbirth was significantly lower in the vaccinated cohort by 15% (pooled OR 0·85; 95% CI 0·73-0·99, 66,067 vaccinated vs. 424,624 unvaccinated, I2 = 93·9%). There was no evidence of a higher risk of adverse outcomes including miscarriage, earlier gestation at birth, placental abruption, pulmonary embolism, postpartum haemorrhage, maternal death, intensive care unit admission, lower birthweight Z-score, or neonatal intensive care unit admission (p &gt; 0.05 for all). COVID-19 mRNA vaccination in pregnancy appears to be safe and is associated with a reduction in stillbirth.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/en/publications/96db0dfc-bc28-4193-9876-6dd2f3265f55
KW - Coronavirus (COVID-19)
ER