TY - GEN
AU - Zhou, Yifan
AU - Shalhoub, Ruba N
AU - Rogers, Stephanie N
AU - Yu, Shiqin
AU - Gu, Muxin
AU - Fabre, Margarete Alice
AU - Quiros, Pedro M
AU - Diangson, Arch
AU - Deng, Wenhan
AU - Anand, Shubha
AU - Lu, Wanhua
AU - Cullen, Matthew
AU - Godfrey, Anna L
AU - Preller, Jacobus
AU - Hadjadj, Jérôme
AU - Jouanguy, Emmanuelle
AU - Cobat, Aurélie
AU - Abel, Laurent
AU - Rieux-Laucat, Frédéric
AU - Terrier, Benjamin
AU - Fischer, Alain
AU - Novik, Laura
AU - Gordon, Ingelise J
AU - Strom, Larisa
AU - Gaudinski, Martin
AU - Lisco, Andrea
AU - Sereti, Irini
AU - Gniadek, Thomas J
AU - Biondi, Andrea
AU - Bonfanti, Paolo
AU - Imberti, Luisa
AU - Zhang, Yu
AU - Dalgard, Clifton L
AU - Dobbs, Kerry
AU - Su, Helen C
AU - Notarangelo, Luigi D
AU - Wu, Colin O
AU - Openshaw, Peter J.M.
AU - Semple, Malcolm Gracie
AU - Mallat, Ziad
AU - Baillie, J. Kenneth
AU - Dunbar, Cynthia E
AU - Vassiliou, George S
PY - 2022
DA - July
TI - Clonal Hematopoiesis Is Not Significantly Associated with Covid-19 Disease Severity
DO - https://doi.org/10.1182/blood.2022015721
AB - Clonal hematopoiesis (CH) describes the disproportionate expansion of a hematopoietic stem cell (HSC) and its progeny, in association with leukemia-associated somatic mutations, most commonly affecting the genes for epigenetic regulators DNMT3A, TET2 and ASXL1. The prevalence and size of such clones rise with age, in association with changes in the driver gene landscape.10 CH is associated with an increased risk of hematologic malignancies, but also of cardiovascular disease (CVD), independently of other known CVD risk factors.11,12 The basis for this increased CVD risk has been linked to hyperinflammatory positive feedback loops driven by increased cytokine release from clonal myeloid cells, particularly interleukin IL-6 and IL-1β.
PB - American Society of Hematology
UR - https://www.research.ed.ac.uk/en/publications/d47d5567-7fb4-4573-b4dc-424bbbb4da7b
KW - Coronavirus (COVID-19)
ER