TY - JOUR
AU - Ho, Antonia
AU - Orton, Richard J.
AU - Tayler, Rachel
AU - Asamaphan, Patawee
AU - Tong, Lily
AU - Smollett, Katherine
AU - Davis, Chris
AU - Manali, Maria
AU - McDonald, Sarah E.
AU - Pollock, Louisa
AU - Evans, Clair
AU - Jim McMenamin
AU - Kirsty Roy
AU - Marsh, Kimberly
AU - Divala, Titus
AU - Holden, Matthew T.G.
AU - Lockhart, Michael
AU - Yirrell, David
AU - Currie, Sandra
AU - Shepherd, Samantha J.
AU - Jackson, Celia
AU - Gunson, Rory N.
AU - MacLean, Alasdair
AU - McInnes, Neil
AU - Battle, Richard
AU - Hollenbach, Jill
AU - Henderson, Paul
AU - Chand, Meera
AU - Hamilton, Melissa Shea
AU - Estrada-Rivadeneyra, Diego
AU - Levin, Michael
AU - DIAMONDS Consortium
AU - ISARIC4C Investigators
AU - Robertson, David A.
AU - da Silva Filipe, Ana
AU - Willett, Brian J.
AU - Breuer, Judith
AU - Semple, Malcolm G.
AU - Turner, David P. J.
AU - Baillie, J. Kenneth
AU - Thomson, Emma C.
PY - 2022
DA - July
TI - Adeno-associated virus 2 infection in children with non-A-E hepatitis
JO - medRxiv
DO - https://doi.org/10.1101/2022.07.19.22277425
AB - An outbreak of acute hepatitis of unknown aetiology in children was first reported in Scotland in April 2022.Cases aged &lt;16 years have since been identified in 35 countries.Here we report a detailed investigation of 9 early cases and 58 control subjects. Using next-generation sequencing and real-time PCR, adeno-associated virus 2 (AAV2), was detected in the plasma of 9/9 and liver of 4/4 patients but in 0/13 sera/plasma of age-matched healthy controls, 0/12 children with adenovirus (HAdV) infection and normal liver function and 0/33 children admitted to hospital with hepatitis of other aetiology. AAV2 typically requires a coinfecting ‘helper’ virus to replicate, usually HAdV or a herpesvirus. HAdV (species C and F) and human herpesvirus 6B (HHV6B) were detected in 6/9 and 3/9 affected cases, including 3/4 and 2/4 liver biopsies, respectively. The class II HLA-DRB1*04:01 allele was identified in 8/9 cases (89%), compared with a background frequency of 15.6% in Scottish blood donors, suggestive of increased susceptibility in affected cases. Acute non-A-E paediatric hepatitis is associated with the presence of AAV2 infection, which could represent a primary pathogen or a useful biomarker of recent HAdV or HHV6B infection. Population and mechanistic studies are required to explore these findings further.
PB - medRxiv
UR - https://publichealthscotland.scot/id/90938
KW - Coronavirus (COVID-19)
KW - Children, young people and families
ER