TY - JOUR AU - Morrow, Andrew J. AU - Gray, Stuart R. AU - Bayes, Hannah K. AU - Sykes, Robert AU - McGarry, E. AU - Anderson, David AU - Boiskin, D. AU - Burke, C. AU - Cleland, John G.F. AU - Goodyear, Carl S. AU - Ibbotson, Tracy R. AU - Lang, Chim C. AU - McConnachie, Alex AU - Mair, Frances S. AU - Mangion, Kenneth AU - Patel, Manish AU - Sattar, Naveed AU - Taggart, Diann AU - Taylor, R. AU - Dawkes, Susan AU - Berry, Colin PY - 2022 DA - August TI - Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise. CISCO-21 JO - Trials VL - 23 IS - 1 DO - https://dx.doi.org/10.1186/s13063-022-06632-y AB - Background: Coronavirus disease-19 (COVID-19) infection causes persistent health problems such as breathlessness, chest pain and fatigue, and therapies for the prevention and early treatment of post-COVID-19 syndromes are needed. Accordingly, we are investigating the effect of a resistance exercise intervention on exercise capacity and health status following COVID-19 infection. Methods: A two-arm randomised, controlled clinical trial including 220 adults with a diagnosis of COVID-19 in the preceding 6 months. Participants will be classified according to clinical presentation: Group A, not hospitalised due to COVID but persisting symptoms for at least 4 weeks leading to medical review; Group B, discharged after an admission for COVID and with persistent symptoms for at least 4 weeks; or Group C, convalescing in hospital after an admission for COVID. Participants will be randomised to usual care or usual care plus a personalised and pragmatic resistance exercise intervention for 12 weeks. The primary outcome is the incremental shuttle walks test (ISWT) 3 months after randomisation with secondary outcomes including spirometry, grip strength, short performance physical battery (SPPB), frailty status, contacts with healthcare professionals, hospitalisation and questionnaires assessing health-related quality of life, physical activity, fatigue and dyspnoea. Discussion: Ethical approval has been granted by the National Health Service (NHS) West of Scotland Research Ethics Committee (REC) (reference: GN20CA537) and recruitment is ongoing. Trial findings will be disseminated through patient and public forums, scientific conferences and journals. PB - Springer Nature UR - http://eprints.gla.ac.uk/276294/ KW - Coronavirus (COVID-19) ER