TY - JOUR
AU - Velu, Prasad P
AU - Lucas, Christopher D.
AU - Conway Morris, Andrew
PY - 2021
DA - September
TI - Post-mortem dissection of COVID-19: a pathogenic role for macrophages?
JO - Intensive Care Medicine
EP - 1325
VL - 47
IS - 11
DO - https://doi.org/10.1007/s00134-021-06509-9
AB - Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention.
PB - Springer Nature
UR - https://www.research.ed.ac.uk/en/publications/49d86028-fb5c-4c72-9d06-1ac89eb2ba91
KW - Coronavirus (COVID-19)
ER