TY - JOUR
AU - Bousquet, Jean
AU - Czarlewski, Wienczyslawa
AU - Zuberbier, Torsten
AU - Mullol, Joaquim
AU - Blain, Hubert
AU - Cristol, Jean-Paul
AU - De La Torre, Rafael
AU - Le Moing, Vincent
AU - Pizarro Lozano, Nieves
AU - Bedbrook, Anna
AU - Agache, Ioana
AU - Akdis, Cezmi A.
AU - Canonica, G. Walter
AU - Cruz, Alvaro A.
AU - Fiocchi, Alessandro
AU - Fonseca, João A.
AU - Fonseca, Susana
AU - Gemicioğlu, Bilun
AU - Haahtela, Tari
AU - Iaccarino, Guido
AU - Ivancevich, Juan Carlos
AU - Jutel, Marek
AU - Klimek, Ludger
AU - Kuna, Piotr
AU - Larenas-Linnemann, Désirée E.
AU - Melén, Erik
AU - Okamoto, Yoshitaka
AU - Papadopoulos, Nikolaos G.
AU - Pfaar, Oliver
AU - Reynes, Jacques
AU - Rolland, Yves
AU - Rouadi, Philip W
AU - Samolinski, Boleslaw
AU - Sheikh, Aziz
AU - Toppila-Salmi, Sanna
AU - Valiulis, Arunas
AU - Choi, Hak-Jong
AU - Kim, Hyun Ju
AU - Antó, Josep M.
PY - 2020
DA - December
TI - Spices to Control COVID-19 Symptoms: Yes, but Not Only…
JO - International Archives of Allergy and Immunology
EP - 495
VL - 182
IS - 6
DO - https://doi.org/10.1159/000513538
AB - There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.
PB - S. Karger AG
UR - https://www.research.ed.ac.uk/portal/en/publications/spices-to-control-covid19-symptoms(dd75f952-58f5-4858-a788-7f4eeb585f23).html
KW - Coronavirus (COVID-19)
KW - Diet, healthy weight and physical activity
ER