TY - JOUR AU - Calvert, Clara AU - Carruthers, Jade AU - Denny, Cheryl AU - Donaghy, Jack AU - Hillman, Sam AU - Hopcroft, Lisa E.M. AU - Hopkins, Leanne AU - Goulding, Anna AU - Lindsay, Laura AU - McLaughlin, Terry AU - Moore, Emily AU - Pan, Jiafeng AU - Taylor, Bob AU - Almaghrabi, Fatima AU - Auyeung, Bonnie AU - Bhaskaran, Krishnan AU - Gibbons, Cheryl L. AU - Katikireddi, Srinivasa Vittal AU - McCowan, Colin AU - Murray, Josephine-Louise K. AU - O'Leary, Maureen AU - Ritchie, Lewis D AU - Shah, Syed Ahmar AU - Simpson, Colin R AU - Robertson, Chris AU - Sheikh, Aziz AU - Stock, Sarah J E AU - Wood, Rachael PY - 2022 DA - October TI - A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection JO - Nature Communications VL - 13 DO - https://doi.org/10.1038/s41467-022-33937-y AB - Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19. PB - Springer Nature UR - https://hdl.handle.net/2164/19398 KW - Coronavirus (COVID-19) KW - Maternity and early years KW - Immunisation and screening ER