- Published
- 03 August 2022
- Journal article
A first update on mapping the human genetic architecture of COVID-19
- Authors
- Source
- Nature
Abstract
The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.
Rights
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Cite as
The COVID-19 Host Genetics Initiative. 2022, 'A first update on mapping the human genetic architecture of COVID-19', Nature, 608, pp. E1-E10. https://doi.org/10.1038/s41586-022-04826-7