COVID-19 and cardiovascular disease: additional risks for patients with chronic kidney disease

Authors: Del Vecchio, Lucia ;

Balafa, Olga;

Dounousi, Evangelia;

Ekart, Robert;

Fernandez Fernandez, Beatriz;

Mark, Patrick B.;

Sarafidis, Pantelis;

Valdivielso, Jose M.;

Ferro, Charles J.;

Mallamaci, Francesca

Source: Nephrology Dialysis Transplantation

Full text

: https://doi.org/10.1093/ndt/gfad170

Abstract

Millions of people worldwide have chronic kidney disease (CKD). Affected patients are at high risk for cardiovascular (CV) disease for several reasons. Among various comorbidities, CKD is associated with the more severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This is particularly true for patients receiving dialysis or for kidney recipients. From the start of the SARS-CoV-2 pandemic, several CV complications have been observed in affected subjects, spanning acute inflammatory manifestations, CV events, thrombotic episodes and arrythmias. Several pathogenetic mechanisms have been hypothesized, including direct cytopathic viral effects on the myocardium, endothelial damage and hypercoagulability. This spectrum of disease can occur during the acute phase of the infection, but also months after recovery. This review is focussed on the CV complications of coronavirus disease 2019 (COVID-19) with particular interest in their implications for the CKD population.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite as

Del Vecchio, L., Balafa, O., Dounousi, E., Ekart, R., Fernandez Fernandez, B., Mark, P., Sarafidis, P., Valdivielso, J., Ferro, C. & Mallamaci, F. 2023, 'COVID-19 and cardiovascular disease: additional risks for patients with chronic kidney disease', Nephrology Dialysis Transplantation, article no: gfad170. https://doi.org/10.1093/ndt/gfad170

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DOI: https://doi.org/10.1093/ndt/gfad170

Repository URI: https://eprints.gla.ac.uk/303343/