Abstract

  • The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.

  • PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalization, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments and to serve as a platform to enable future studies, including clinical trials.

  • Data collected covered a wide range of physical measures, biological samples and patient-reported outcome measures (PROMs).

  • Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA; or in Tier 2 in which they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at 5 (range 2–7) months and 12 (range 10–14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.

  • All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.

  • In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.

  • Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals from https://www.phosp.org/data-sample-request/.

Rights

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite as

Elneima, O., McAuley, H., Leavy, O., Chalmers, J., Horsley, A., Ho, L., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Harris, V., Houchen-Wolloff, L., Saunders, R., Greening, N., Richardson, M., Quint, J., Briggs, A., Docherty, A., Kerr, S., Harrison, E., Lone, N., Thorpe, M., Heaney, L., Lewis, K., Aul, R., Beirne, P., Bolton, C., Brown, J., Choudhury, G., Diar Bakerly, N., Easom, N., Echevarria, C., Fuld, J., Hart, N., Hurst, J., Jones, M., Parekh, D., Pfeffer, P., Rahman, N., Rowland-Jones, S., Thompson, A., Jolley, C., Shah, A., Wootton, D., Chalder, T., Davies, M., De Soyza, A., Geddes, J., Greenhalf, W., Heller, S., Howard, L., Jacob, J., Jenkins, R., Lord, J., Man, W., McCann, G., Neubauer, S., Openshaw, P., Porter, J., Rowland, M., Scott, J., Semple, M., Singh, S., Thomas, D., Toshner, M., Sheikh, A., Brightling, C., Wain, L. & Evans, R. 2023, 'Cohort profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)', International Journal of Epidemiology, 53(1), article no: dyad165. https://doi.org/10.1093/ije/dyad165

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Last updated: 07 March 2024
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