Can the Environmental Phagocyte Acanthamoeba Be a Useful Model to Study SARS-CoV-2 Pathogenicity, Infectivity, and Evasion of Cellular Immune Defenses?

Authors: Siddiqui, Ruqaiyyah;

Khan, Naveed Ahmed

Source: ACS Chemical Neuroscience

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: https://doi.org/10.1021/acschemneuro.0c00401

Abstract

Acanthamoeba and macrophages exhibit significant parallels in biochemical, physiological, cellular, and functional aspects. Given the ability of Acanthamoeba to contribute to the evolutionary gain of pathogenicity of a variety of microbial pathogens, here we propose the use of Acanthamoeba as a paradigm to study SARS-CoV-2 pathogenicity, infectivity, and evasion of cellular immune defenses.

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Siddiqui, R. & Khan, N. 2020, 'Can the Environmental Phagocyte Acanthamoeba Be a Useful Model to Study SARS-CoV-2 Pathogenicity, Infectivity, and Evasion of Cellular Immune Defenses?', ACS Chemical Neuroscience, 11(15), pp. 2149-2151. https://doi.org/10.1021/acschemneuro.0c00401

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DOI: https://doi.org/10.1021/acschemneuro.0c00401

Repository URI: https://researchportal.hw.ac.uk/en/publications/7ac19ef4-3486-484f-b23b-c8534e226af6