Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study - Repository

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: https://doi.org/10.4103/hm.HM-D-23-00037

Abstract

Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function.

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Berry, C., Lomholt-Welch, H., Morrow, A., Sykes, R., Saleh, M., Zahra, B., MacIntosh, A., Kamdar, A., Bagot, C., Bayes, H., Blyth, K., Bulluck, H., Carrick, D., Church, C., Corcoran, D., Findlay, I., Gibson, V., Gillespie, L., Grieve, D., Barrientos, P., Ho, A., Lang, N., Lowe, D., Lennie, V., Macfarlane, P., Mayne, K., Mark, P., McConnachie, A., McGeoch, R., Nordin, S., Payne, A., Rankin, A., Robertson, K., Ryan, N., Roditi, G., Sattar, N., Stobo, D., Touyz, R., Veldtman, G., Weeden, S., Weir, R., Watkins, S., Welsh, P., Mangion, K. & Allwood-Spiers, S. 2023, 'Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study', Heart and Mind, 7(4), pp. 235-245. https://doi.org/10.4103/hm.HM-D-23-00037

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DOI: https://doi.org/10.4103/hm.HM-D-23-00037

Repository URI: https://eprints.gla.ac.uk/321139/