- Published
- 15 June 2021
- Journal article
Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review
- Authors
- Source
- Journal of Neuroimmunology
Abstract
Objective: The systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.
Methods: After protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann–Whitney U test, were used. P < 0.05 was considered significant.
Results: We identified 64 relevant articles. The mean age of the patients was 56 ± 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05).
Conclusions: GBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.
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Cite as
Baker Sheikh, A., Chourasia, P., Javed, N., Kumar Chourasia, M., Suriya, S., Upadhyay, S., Ijaz, F., Pal, S., Moghimi, N. & Shekhar, R. 2021, 'Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review', Journal of Neuroimmunology, 355, article no: 577577. https://doi.org/10.1016/j.jneuroim.2021.577577