Biomolecular interactions with nanoparticles : applications for COVID-19

Authors: Farouq, Mohammed A.H. ;

Al Qaraghuli, Mohammed M.;

Kubiak-Ossowska, Karina;

Ferro, Valerie A.;

Mulheran, Paul A.

Source: Current Opinion in Colloid & Interface Science

Full text

: https://doi.org/10.1016/j.cocis.2021.101461

Abstract

Nanoparticles are small particles sized 1–100 nm, which have a large surface-to-volume ratio, allowing efficient adsorption of drugs, proteins, and other chemical compounds. Consequently, functionalized nanoparticles have potential diagnostic and therapeutic applications. A variety of nanoparticles have been studied, including those constructed from inorganic materials, biopolymers, and lipids. In this review, we focus on recent work targeting the severe acute respiratory syndrome coronavirus 2 virus that causes coronavirus disease (COVID-19). Understanding the interactions between coronavirus-specific proteins (such as the spike protein and its host cell receptor angiotensin-converting enzyme 2) with different nanoparticles paves the way to the development of new therapeutics and diagnostics that are urgently needed for the fight against COVID-19, and indeed for related future viral threats that may emerge.

Rights

Cite as

Farouq, M., Al Qaraghuli, M., Kubiak-Ossowska, K., Ferro, V. & Mulheran, P. 2021, 'Biomolecular interactions with nanoparticles : applications for COVID-19', Current Opinion in Colloid & Interface Science, 54, article no: 101461. https://doi.org/10.1016/j.cocis.2021.101461

Downloadable citations

HTML BIB RIS

Identifiers

DOI: https://doi.org/10.1016/j.cocis.2021.101461

Repository URI: https://strathprints.strath.ac.uk/76238/