The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages - Repository

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: http://dx.doi.org/10.1016/j.cell.2021.09.003

Abstract

The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three “501Y lineages” coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.

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Martin, D., Weaver, S., Tegally, H., San, J., Shank, S., Wilkinson, E., Lucaci, A., Giandhari, J., Naidoo, S., Pillay, Y., Singh, L., Lessells, R., Gupta, R., Wertheim, J., Nekrutenko, A., Murrell, B., Harkins, G., Lemey, P., MacLean, O., Robertson, D., De Oliveira, T. & Kosakovsky Pond, S. 2021, 'The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages', Cell, 184(20), pp. 5189-5200.e7. http://dx.doi.org/10.1016/j.cell.2021.09.003

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DOI: http://dx.doi.org/10.1016/j.cell.2021.09.003

Repository URI: http://eprints.gla.ac.uk/252906/