- Published
- 21 June 2022
- Journal article
Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers
- Authors
-
- Source
- Scientific Reports
Abstract
Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure.
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Cite as
Kemp, S., Cheng, M., Hamilton, W., Kamelian, K., Chauhan, H., Dikid, T., Gogia, H., Lall, H., Ponnusamy, K., Verma, K., Dhar, M., Singh, M., Datta, M., Soni, N., Meena, N., Madan, P., Singh, P., Sharma, R., Sharma, R., Kabra, S., Kumar, S., Kumari, S., Sharma, U., Chaudhary, U., Sivasubbu, S., Scaria, V., Wattal, C., Oberoi, J., Raveendran, R., Datta, S., Das, S., Maitra, A., Chinnaswamy, S., Biswas, N., Parida, A., Raghav, S., Prasad, P., Sarin, A., Mayor, S., Ramakrishnan, U., Palakodeti, D., Seshasayee, A., Thangaraj, K., Bashyam, M., Dalal, A., Bhat, M., Shouche, Y., Pillai, A., Abraham, P., Potdar, V., Cherian, S., Desai, A., Pattabiraman, C., Manjunatha, M., Mani, R., Udupi, G., Nandicoori, V., Tallapaka, K., Sowpati, D., Singh, S., Rakshit, P., Agrawal, A., Illingworth, C. & Gupta, R. 2022, 'Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers', Scientific Reports, 12(1), article no: 10492. http://dx.doi.org/10.1038/s41598-022-14411-7
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- Repository URI
- http://eprints.gla.ac.uk/273627/