- Published
- 15 July 2022
- Letter
Clonal Hematopoiesis Is Not Significantly Associated with Covid-19 Disease Severity
- Authors
-
- Source
- Blood
Full text
Abstract
Clonal hematopoiesis (CH) describes the disproportionate expansion of a hematopoietic stem cell (HSC) and its progeny, in association with leukemia-associated somatic mutations, most commonly affecting the genes for epigenetic regulators DNMT3A, TET2 and ASXL1.
The prevalence and size of such clones rise with age, in association with changes in the driver gene landscape.10 CH is associated with an increased risk of hematologic malignancies, but also of cardiovascular disease (CVD), independently of other known CVD risk factors.11,12 The basis for this increased CVD risk has been linked to hyperinflammatory positive feedback loops driven by increased cytokine release from clonal myeloid cells, particularly interleukin IL-6 and IL-1β.
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Cite as
Zhou, Y., Shalhoub, R., Rogers, S., Yu, S., Gu, M., Fabre, M., Quiros, P., Diangson, A., Deng, W., Anand, S., Lu, W., Cullen, M., Godfrey, A., Preller, J., Hadjadj, J., Jouanguy, E., Cobat, A., Abel, L., Rieux-Laucat, F., Terrier, B., Fischer, A., Novik, L., Gordon, I., Strom, L., Gaudinski, M., Lisco, A., Sereti, I., Gniadek, T., Biondi, A., Bonfanti, P., Imberti, L., Zhang, Y., Dalgard, C., Dobbs, K., Su, H., Notarangelo, L., Wu, C., Openshaw, P., Semple, M., Mallat, Z., Baillie, J., Dunbar, C. & Vassiliou, G. 2022, 'Clonal Hematopoiesis Is Not Significantly Associated with Covid-19 Disease Severity', Blood. https://doi.org/10.1182/blood.2022015721