(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Abstract

Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality.

The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS‐CoV‐2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19.

In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

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http://creativecommons.org/licenses/by/4.0/

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DOI

https://doi.org/10.1016/j.jmccpl.2022.100013

Repository URI

https://www.research.ed.ac.uk/en/publications/2244535a-cbff-41f6-a16c-e3dc7d08bcb0