Post-mortem dissection of COVID-19: a pathogenic role for macrophages?

Authors: Velu, Prasad P;

Lucas, Christopher D. ;

Conway Morris, Andrew

Source: Intensive Care Medicine

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: https://doi.org/10.1007/s00134-021-06509-9

Abstract

Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention.

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Velu, P., Lucas, C. & Conway Morris, A. 2021, 'Post-mortem dissection of COVID-19: a pathogenic role for macrophages?', Intensive Care Medicine, 47(11), pp. 1322-1325. https://doi.org/10.1007/s00134-021-06509-9

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DOI: https://doi.org/10.1007/s00134-021-06509-9

Repository URI: https://www.research.ed.ac.uk/en/publications/49d86028-fb5c-4c72-9d06-1ac89eb2ba91