Mpox guidance for health protection teams
Version 1.11

• Updated vaccination advice for clade II mpox to reflect changes in the UKHSA contact tracing matrix.

• HCID mpox case definition updated to add that transit through an affected country without leaving the airport does not count as travel to that country
• Links to UKHSA guidance on reducing risk of transmission at vaccination clinics added
• Links to cleaning guidance for non-healthcare settings added
• Links to case isolation sheet added

• Testing section updated to add SVC to the list of laboratories offering HCID mpox testing

• Case definition links updated based on changes to case definition and lay-out of country list by UKHSA

• Change of name from monkeypox to mpox throughout when referring to the disease only
• Updated guidance to include differential public health management of HCID and non-HCID clades in response to outbreak of clade I (HCID) mpox in DRC and neighbouring countries.
• References to 2022 outbreak updated throughout.
• Case definitions updated based on changes by UKHSA.

• Updated the management of suspected HCID cases section.

• Updated clinical features section with link to Tecovirimat clinical policy.
• Updated notification requirement section with HCID clade lineage information.

• Updated symptom list in case definition.
• Updated actions for probable and possible cases.
• Updated household pets advice.
• Aligned with Green Book chapter update.
• Added blood, tissue, organ donation section.
• Revised clade nomenclature to align with WHO.

• Updated case definition.
• Information in transmission routes section updated.
• Added advice to notify cases their details may be shared during flight and international contact tracing for specific purposes.
• Addition of CMO letter link to the pre and post-exposure vaccination section.

• Remove links to  primary and community care guidance (archived).
• Align with UKHSA changes:
  • HCID status (derogation) and waste re-categorisation.
  • Updated Principles consensus statement.
  • Change to condom usage advice (12 weeks instead of 8) (new guidance).
  • Updated case def symptomology (proctitis added).
  • Updated contact tracing.
  • Updated PHS labs information note.
  • Updates case/contact information sheets.
  • Clarify wording on de-isolation.
  • Add links to new UKHSA guidance (events and mass gatherings).
  • Add link to Autopsy HSE guidance.
  • Isolation support.

• Move to passive surveillance of all contacts – active surveillance no longer required.
• Disposal of home testing waste clarified.
• APHA guidance on pet ownership added.

First publication.