- Published
- 17 October 2022
- Journal article
A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection
- Authors
-
- Source
- Nature Communications
Abstract
Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
Rights
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Cite as
Calvert, C., Carruthers, J., Denny, C., Donaghy, J., Hillman, S., Hopcroft, L., Hopkins, L., Goulding, A., Lindsay, L., McLaughlin, T., Moore, E., Pan, J., Taylor, B., Almaghrabi, F., Auyeung, B., Bhaskaran, K., Gibbons, C., Katikireddi, S., McCowan, C., Murray, J., O'Leary, M., Ritchie, L., Shah, S., Simpson, C., Robertson, C., Sheikh, A., Stock, S. & Wood, R. 2022, 'A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection', Nature Communications, 13, article no: 6124. https://doi.org/10.1038/s41467-022-33937-y
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- Repository URI
- https://hdl.handle.net/2164/19398